chlorpromazine-induced hyperprolactinemia on rat’s uterus

نویسندگان

zahra zamani

samad zare

rajabali sadrkhanlou

abbas ahmadi

چکیده

background: hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation. the current study was designed to evaluate dose-dependent effect of chlorpromazine (cpz) on hormonal changes and uterine horn histological structure in rats. moreover, the mammary glands were analyzed to show hyperprolactinemia-induced histological changes. methods: albino wistar rats (n = 32) were divided into four groups. the first group was set as a control. in the three drug-treated groups (eight rats in each group), cpz was administered by a gavage at doses of 3, 10, and 30 mg/kg/day for 28 days. one day after the last administration of the drug, the animals were sacrificed. histopathological and histomorphometrical analyses of the uterine horns and mammary glands were carried out to evaluate dose-dependent effect of cpz on histological structure. serum levels of prolactin (prl), estradiol, progesterone, follicle-stimulating hormone (fsh), and luteinizing hormone (lh) were also evaluated. results: remarkable (p < 0.05) elevation was observed in cpz-administrated animals&apos; uterine horn endometrium, myometrium, and perimetrium thicknesses, and the mammary glands were observed with galactorrhea features. the serum level of progesterone and prl significantly (p < 0.05) increased, while the serum concentration of lh, fsh, and estradiol was notably (p < 0.05) decreased depending on administrated cpz dose. no histological and biological changes were occurred in the control animals. conclusion: the present findings suggest that cpz-induced disturbances not only depend on prl level and increased prl level largely depends on administrated doses of the cpz.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Chlorpromazine-Induced Hyperprolactinemia on Rat’s Uterus

Background: Hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation. The current study was designed to evaluate dose-dependent effect of chlorpromazine (CPZ) on hormonal changes and uterine horn histological structure in rats. Moreover, the mammary glands were analyzed to show hyperprolactinemia-induced histological changes. Methods: Albino Wistar r...

متن کامل

Chlorpromazine-Induced Hyperprolactinemia on Rat’s Uterus

BACKGROUND Hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation. The current study was designed to evaluate dose-dependent effect of chlorpromazine (CPZ) on hormonal changes and uterine horn histological structure in rats. Moreover, the mammary glands were analyzed to show hyperprolactinemia-induced histological changes. METHODS Albino Wistar r...

متن کامل

[Hyperprolactinemia effects on the female mice uterus during proestrous].

PURPOSE To evaluate the effect of hyperprolactinemia induced by metoclopramide on the endometrium and myometrium of female mice in the proestrus phase. METHODS 24 female mice were randomly divided in two groups: CtrG/control and ExpG/treated with metoclopramide (6.7 mg/g daily). After 50 days, the animals were sacrificed in the proestrus phase, and the blood was collected to determine the lev...

متن کامل

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats.

This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitone...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian biomedical journal

جلد ۱۹، شماره ۴، صفحات ۲۲۶-۲۳۲

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023